Abbreviations, Acronyms, Terms

See Glossary for key definitions and Appendix 2 for information on spelling style.

Abbreviation	Definition
2‑5A	2′‑5′‑oligoadenylate
AAV2‑REP1	adeno-associated virus-2 vector construct that encodes REP1
ALI	air-liquid interface
AM	alveolar macrophages
ATP	adenosine triphosphate
CXCL10	(gene & protein) C-X-C motif chemokine ligand 10
CXCR3	(gene & protein) C-X-C motif chemokine receptor 3
DGE	differential genetic expression (in cell cultures)
DNA	deoxyribonucleic acid
dsRNA	double-stranded RNA (viruses)
GWAS	genome-wide association studies
GXA	Gene Expression Atlas
HAEC	human airway epithelial cells
HDAC	histone deacetylase
HPA	Human Protein Atlas
HRV16, HRV	human rhinovirus RV‑A16
hrv-ast (α)	HRV16 treatment on asthmatic tissue
hrv-non (γ)	HRV16 treatment on non-asthmatic tissue
IFN	interferon, a type of cytokine
IFNα, IFNβ	Cytokines, type‑I interferons (IFN)
IFNγ	A cytokine, the only member of type II class of interferons (IFN)
IRF9	Interferon regulatory factor 9; previously known as ISGF3G
ISG	interferon-stimulated gene
ISGF	interferon-stimulated gene factor
ISRE	interferon-stimulated response element
JAK	Janus kinases
JAK‑STAT	Janus kinase/signal transducers and activators of transcription
KEGG	Kyoto Encyclopedia of Genes and Genomes
NCBI	National Center for Biotechnology Information
ncRNA	non-coding RNA
NF‑κB	nuclear factor kappa-light-chain-enhancer of activated B cells
NHLBI	National Heart, Lung, and Blood Institute
NIH	National Institutes of Health
NLM	National Library of Medicine
OAS*	(genes) oligoadenylate synthase
ORMDL3	(gene & protein) ORMDL Sphingolipid Biosynthesis Regulator 3
OU	The Open University
PIAS	protein inhibitors of activated STAT
qPCR	Quantitative PCR (a real-time polymerase chain reaction)
RIG-1	(gene) retinoic acid-inducible gene-I
RNA	ribonucleic acid
RNase	Ribonuclease, the RNA degrader
RNaseL	Ribonuclease L, L for latent, cleaves all RNA in a cell
RNA-seq	RNA sequencing technique using next-generation sequencing
RSV	respiratory syncytial virus
RV	rhinovirus
SAHA	suberoylanilide hydroxamic acid (vorinostat)
SCA	Single Cell Atlas
SOCS	proteins - suppressors of cytokine signalling
SOCS*	(genes) suppressors of cytokine signalling
STAT*	(genes) signal transducers and activators of transcription
STATα	Full-length STAT protein.
STATβ, STATγ	C-terminally truncated forms isoforms of STAT proteins. Inhibit STATα function by binding to STAT binding sites.
TF	transcription factor
TJ	tight junctions
TWAS	transcriptome-wide association studies
TYK	tyrosine kinases
USP18	Ubiquitin-Specific Peptidase 18
veh-ast (β)	vehicle treatment on asthmatic tissue
veh-non (δ)	vehicle treatment on non-asthmatic tissue
W	Wilcoxon test statistic, the smaller of the rank totals